MUTATION ANALYSIS OF THE NRXN1 GENE IN AUTISM SPECTRUM DISORDERS

The aim of this study was to identify the sequence mutations in the Neurexin 1 (NRXN1) gene that has been considered as one of the strong candidate genes.A total of 30 children and adolescents (aged 3-18) with non syndromic autism were enrolled this study.Sequencing of the coding exons and the exon-intron boundaries of the NRXN1 gene was performed.

Background & objective: Due to the features such as intuitive graphical appearance, ease of perception and straightforward applicability, risk matrix has become as one of the most used risk assessment tools.On the other hand, features such as the lack of precision in the classification of risk index, as well as subjective computational process, has